Endometrial Receptivity Analysis

ERA is a genetic test that determines the optimal time for an embryo to be implanted into a woman’s uterus during assisted reproductive procedures like IVF. Read till the end to know about ERA in detail.

About Endometrial Receptivity Analysis (ERA)

ERA stands for Endometrial Receptivity Analysis. It is a generic test to know when it is most suitable to transfer an embryo. A general IVF timeline might not be appropriate for every woman because each woman’s physiology is different. ERA greatly increases the likelihood of conception by enabling fertility specialists to determine the optimal timing for implantation.

Why is the ERA Test Done?

The ERA test is done to help doctors find the ideal time to place an embryo into the uterus. Finding the best time is important to increase the chances of pregnancy. It is mostly recommended for women who have had multiple IVF failures, even after having a healthy embryo. By using the ERA test, doctors can modify the time of embryo transfer to increase the likelihood of a healthy pregnancy.

How is ERA done?

Prepare for embryo transfer

During this process, the patient undergoes hormone regimen to prepare the endometrium for embryo transfer. The doctor closely monitors the patient to track the development of the endometrial lining.

Endometrial Biopsy

An endometrial biopsy is a procedure performed to obtain a small sample of endometrial tissue to ascertain when the endometrial lining is ready for implantation. This is done during the luteal phase (after ovulation / after progesterone hormone supplementation).

Genetic Analysis

The endometrial tissue sample is forwarded to a lab for genetic analysis. To ascertain whether the endometrium is in the ideal window of receptivity, the lab examines the expression of particular genes that are essential for implantation.

Results and Recommendations

Following testing, the result shows whether or not the endometrial tissue is responsive at the time of the biopsy. If the endometrium is not receptive, the test will provide personalized recommendations about the next embryo transfer.

Optimal Transfer Timing

If the endometrium is receptive at a different period than anticipated, the embryo transfer cycle is modified to match the ideal window of implantation. This increases the likelihood of a successful pregnancy.

Significance of Endometrial Receptivity Analysis

The ERA treatment is most suitable for women who have faced multiple pregnancy failures. Its importance is:

Is ERA Treatment Right for Me?

Endometrial receptivity analysis (ERA) is recommended for patients who have faced multiple pregnancy failures or have a history of unsuccessful embryo implantation. Often, despite a spate of favourable parameters like high-quality embryos, a healthy uterus, and sufficient endometrial thickness, the implantation fails to occur due to the transfer of the embryo at the wrong time. Additionally, those whose endometrial thickness varies from cycle to cycle and does not always meet the 7 millimeter standard. For these people, ERA treatment is recommended.

Success Rate of Endometrial Receptivity Analysis (ERA)

In women who have experienced repeated implantation failures, the use of ERA significantly increases the success rate of embryo implantation by up to 80% . In patients with a favourable prognosis, ERA increases IVF pregnancy outcomes and the greatest improvement is observed in implantation.

For more details about the ERA test get in touch with Dr. Anju Yadav! She has an experience of more than 17 years in infertility treatment, with her immense knowledge she has helped various people in conceiving a child.

Frequently Asked Questions

Q. What is the ERA cost for IVF?

The Endometrial Receptivity Array (ERA) cost in Gurugram varies approximately from Rs. 40000 to 50000, depending on the clinic, location, and specific medications required.

Q. Is the ERA Test Painful?

The Endometrial Receptivity Analysis test is usually less painful. It involves a minor discomfort or cramping, but it is not highly unpleasant. It is easily tolerable by the majority of women. After consulting the doctor, you can use painkillers to get relief from pain.

Q. Can someone who experiences multiple IVF failures benefit from ERA?

Yes, ERA is most suitable for patients who experience repeated implantation failures. It tells about the right time of embryo transfer, which often results in a successful pregnancy.

Q. Is there any risk of an ERA test?

The ERA (Endometrial Receptivity Array) does not involve any major risk. It is generally safe but involves a minimally invasive biopsy that can cause mild cramps, spotting or irritation, with a slight infection.